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Table 2 Number of sequenced individuals, distribution of sequencing coverages, total coverage, and total investment for the different populations with the Combined method with variable or uniform coverage

From: Evaluation of sequencing strategies for whole-genome imputation with hybrid peeling

PedigreeVariable coverageaUniform coverage at equal total coveragebUniform coverage at equal investmentcCoverage of 2× at equal investmentd
 Number of individuals sequencedTotal coverage (x)Investment (MUe)Individual coverage (x)Investment (MUe)Individual coverage (x)Number of individuals sequenced
Total1x2x5x15x30x
2 × 20002231614708758538,6702.6255,7201.67193
5 × 200056140311912711138195,4502.46132,9201.63477
10 × 20001130813237456202747191,7202.43264,9601.62958
15 × 2000170312233551189254073288,3502.39393,9601.621441
Real 15k877632182350102061147,0602.35199,9601.60735
Real 30k16421245281976313922273,9102.39379,4401.591369
Real 65k3742271177337156658732629,4502.33848,2401.603147
  1. aResults obtained with the Combined method with an investment equivalent to 5% of the population sequenced at 2×
  2. bTotal coverage obtained with the Combined method distributed uniformly across the same individuals
  3. cInvestment allocated with the Combined method distributed uniformly across the same individuals
  4. dInvestment allocated with the Combined method distributed uniformly across as many individuals as can be sequenced at 2×
  5. eMonetary units
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Genetics Selection Evolution

ISSN: 1297-9686